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Causes Of Alzheimer's Disease Damage


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Causes of Alzheimer's disease

Beta amyloid is a misformed protein found in the brain with toxic effects that damage the nerve cells.

It is considered one of the probable causes of the brain damage associated with Alzheimer's disease.

Preliminary research shows theanine from green tea inhibits brain damage and neurotoxicity from beta amyloid.

Theanine protects brain and memory

Researchers provided theanine for five weeks in the drinking water of mice, who were then injected with amyloid beta (Abeta).

Results showed that theanine significantly

  • reduced memory loss or impairment,

  • reduced the levels of beta amyloid,

  • reduced brain cell death in the cortex and hippocampus,

  • and reduced protein and lipid damage from oxidation

compared to controls.

Pathways included suppression of extracellular signal-regulated kinase (ERK) and NF-kappaB (nuclear factor), as well as reduction of oxidative damage (Kim, L-theanine, an amino acid in green tea, attenuated beta-amyloid-induced cognitive dysfunction and neurotoxidity: Reduction of oxidative damages and inactivation of ERK/p38 kinase and NF-kappaB pathways, Free Radic Biol Med, September 2009).

Alzheimer's disease

This disease currently affects over 5 million people in the United States, and 35 million globally.

It is the seventh leading cause of death, and triples the health care cost of these patients to over $148 billion in the United States(Alz.org) and $315 billion globally.

This disease is expected to rise sharply over the next few decades with the aging of the baby boomer population.

Theanine is a rare amino acid found in green tea.

Alzheimer's Disease Lipid Granule in a Human Brain
Alzheimer's...
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This page last updated by Sharon Jones.

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