Pathophysiology Of Lung Cancer, Theanine Green Tea Research

The pathophysiology of lung cancer includes the growth and migration of the carcinoma cells.



Researchers have examined the effects of theanine from green tea on these cells.

Using the human non-small cell lung cancer A549 line, they found that theanine

• suppressed the growth of carcinoma both in vitro and in vivo

• inhibited the cellular migration

• and strongly suppressed the invasion (metastasis) of these cancerous cells.

In addition, theanine increased the anti-cancer activity of the chemotherapy drugs trichostatin A (an inhibitor of histone deacetylase), berbamine, and norcantharidin (Liu, Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells, Cytotechnology, September 2009).

This research is considered preliminary.

Non-small cell carcinoma accounts for over 80% of lung cancers.

How many people die from lung cancer each year?

The CDC reports that 90,139 men and 69,078 women died in 2005, while 107,416 men and 89,271 women were newly diagnosed with all the lung cancers in the United States as of that year.

Globally, over 1.35 million people were diagnosed and over 1.18 million died from this disease as of 2002 (American Cancer Society).

Theanine from green tea is a rare amino acid with multiple health benefits.

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