Telomerase Cancer Research Using EGCG From Green Tea

EGCG or epigallocatechin gallate, is the primary antioxidant polyphenol catechin found abundantly in green tea.

Using laryngeal squamous cell carcinoma cells, one of the common tumors in head and neck cancers, researchers found that EGCG

• decreased the carcinoma cell viability

• inhibited the cancer's growth and proliferation (metastasis)

• induced apoptosis or cancer cell death

• increased the activity of caspase-3

• and increased telomerase inhibition in a dose-dependent fashion (Wang, Apoptosis induction effects of EGCG in laryngeal squamous cell carcinoma cells through telomerase repression, Arch Pharm Res, September 2009).

Research on how to stop telomerase in cells is still preliminary. The telomeres on the end of DNA strands in all cells are also associated with anti-aging.

It is estimated that over 55,000 Americans will be diagnosed with head and neck cancers this year, and over 13,000 will die from them.

New research has found over 231 genes associated with these cancers (Worsham, DNA hypermethylation markers of poor outcome in layrngeal cancer, Henry Ford Hospital, October 2009).

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