Prostate Cancer News: Jasmine And Prostate Cancer
Methyl jasmonate from jasmine flowers, and other jasmine flower derivatives have shown promise in the fight against cancer, according to research over the last decade.
Recently, a cell study has shown that methyl jasmonate and cis-jasmone have tumor-killing properties.
Advanced prostate cancer cells that not dependent on hormones, are highly resistant to chemotherapy and cell death (apoptosis).
When two cell lines of advanced prostate cancer were exposed to the jasmine flower derivatives, cancer cell growth was inhibited, cancer cell cycles were arrested, and cancer cells died.
The addition of these jasmine derivatives activated caspase 3 and tumor necrosis factor receptor 1 in the tumor cells, leading to apoptosis (Yeruva L, Delayed cytotoxic effects of methyl jasmonate and cis-jasmone induced apoptosis in prostate cancer cells, Cancer Investigations, November 2008).
Prostate Cancer News: Belly Fat Increases Prostate Cancer Risk
The Prospective Investigation into Cancer and Nutrition has followed over 350,000 middle-aged people in Europe for almost a decade.
Checking on 129,502 men who were cancer-free at the beginning of the study, researchers found 2,446 men developed prostate cancer during this time.
Researchers compared BMI (body mass index), waist circumference, and waist-to-hip ratio of the men who developed prostate cancer and the men who remained cancer-free.
Men with low BMI (thin men) but with the highest amount of belly fat (waist measurement) and waist-to-hip ratio showed the greatest risk of developing advanced prostate cancer (Pischon T, Body size and risk of prostate cancer in the European prospective investigation into cancer and nutrition, Cancer Epidemiology Biomarkers Prevention, November 2008).
A healthy waist measurement for the men was less than less than 80 cm or 31.5 inches.
Learn more about belly fat in men here.
Here's research on the fastest belly fat diet.
Prostate Cancer News: Prostate Cancer Inhibited By EGCG Plus Taxol
Many cancers, such as breast cancer and prostate cancer, can be difficult to treat because of interactions with hormonal systems.
A new preliminary study has tested prostate cancer cell lines with EGCG and Taxol.
EGCG was an effective inhibitor of the prostate cancer cell growth, and was synergistically more effective when combined with Taxol.
Other chemicals that were effective with Taxol include genistein and pyrrolidine dithiocarbamate. Vitamin E was only effective at very high doses.
The effective combinations were all able to simultaneously cause cancer cell death, induce the sub-G1 phase of the prostate cancer cell cycle, increase caspase activity, and decrease Bcl-2 expression (Ping SY, Taxol synergizes with antioxidants in inhibiting hormonal refractory prostate cancer cell growth, Urologic Oncology, September 2008).
Does green tea reduce the risk of prostate cancer?
Prostate Cancer News: Prostate Cancer And High Cholesterol
While the primary risk factor for prostate cancer is age (80% of men over age 80 will acquire prostate cancer), researchers interested in preventing prostate cancer have examined other possible associations, including cholesterol levels.
In a recent study, researchers examined 312 white men with prostate cancer, age 50 to 74 years old, and 319 matched controls.
They confirmed that high cholesterol was associated with a statistically significant 64% increased risk of prostate cancer. They also found that high LDL levels were associated with increased prostate cancer.
In addition, men who currently smoked had an 84% higher risk of prostate cancer than men who had never smoked (Magura L, Hypercholesterolemia and prostate cancer: a hospital-based case-control study, Cancer Causes and Control, August 2008).
Early detection is vital for prostate cancer treatment. Men at higher risk who need testing include men over age 55, African-American men, and men with a family history of prostate cancer.
Prostate Cancer News: Strange PSA Screening Argument
The U. S. Preventive Services Task Force has made an official recommendation that MD's should discontinue PSA screening of men over the age of 75 years.
Because PSA screening may be helpful only if men are going to live for another 10 years. On the average, most men don't live over 85 years.
But what if they do?
In addition, men who have health problems that might lead to their death within the next 10 years should not have a PSA screening.
But what if they recover from their health condition?
Dr. LeFevre of the Task Force says about men over age 75, "screening them can do more harm than good."
In what way is the screening harmful?
Because the screening leads to treatments that can cause erectile dysfunction, bladder control problems, and colon problems.
If the harm comes from the treatments rather than the screening, reconsider the treatments.
The PSA screening is certainly not perfect, with some studies showing only a 63% accuracy.
But health care professionals should not remove a source of early detection because statistics say people are going to die anyway.
Early detection, however imperfect, is still the best hope we have.
Learn about prostate cancer risk reduction studies here
Prostate Cancer News: EGCG And Prostate Cancer
A new animal study examined the effect of EGCG (epi-gallocatechin gallate) from green tea, and a new peracetate form of EGCG from green tea on prostate cancer.
Researchers found that both EGCG and EGCG peracetate suppressed the growth of implanted prostate cancer without side effects.
Not only did both forms of EGCG increase apoptosis (cancer cell death) of the prostate cancer cells, but also inhibited tumor angiogenesis. The growth inhibition and prostate cancer cell death from EGCG was also associated with a decrease in serum PSA levels (Lee SC, Effect of a prodrug of the green tea polyphenol (-)-eipgallocatechin-3-gallate on the growth of androgen-independent prostate cancer in vivo, Nutrition and Cancer, July 2008).
Whole green tea extract has also shown a remarkable 90% risk reduction of prostate cancer in men with high-grade PIN, as well as up to 91% reduced risk of prostate cancer with extended green tea drinking.
Can Men Avoid A Double Whammy?
As men grow older, their risk of prostate cancer increases.
Older people who break their hips have a dramatically increased risk of death within six months to a few years.
Now two studies show that men who develop prostate cancer have a much greater risk of breaking their hips, dramatically increasing the danger to their health--a double whammy.
Researchers have tracked 822 Danish men over age 60 for almost 20 years. Men who developed prostate cancer had a 50% greater risk of fractured bones. And when those men had received androgen deprivation therapy, the risk of fracture was almost doubled (Nguyen T, Bone 2008).
An earlier study showed that men age 50 to 65 with prostate cancer had an eight times greater risk of breaking their hips. The average rate of hip fracture for all men with prostate cancer was four times greater than men without prostate cancer.
That study followed 62,865 men. In general prostate cancer was associated with almost double the risk of fractures and almost four times greater risk of fractured hips.
Again, both androgen deprivation therapy and orchidectomy patients had the greatest risk of fracture (Abrahamsen B, Fracture risk in Danish men with prostate cancer: a nationwide register study, BJU International Octuber 2007).
Can men change their future with prostate cancer risk reduction? Check out the research here.
Prostate Cancer News: Detect Cancer Earlier
Finding cancer earlier can save your life.
If cancer is detected in the earliest stages, survival rates can stay close to 100%. If it is detected in the last stages, survival drops to below 20% or may be incurable.
Now there is new technology being developed at the Norwegian University of Science and Technology in Trondheim, Norway, that can find cancerous tissue earlier than current diagnostic techniques.
This new technology is called SURF imaging or Second Order Ultrasound Field imaging.
Using ultrasound for diagnostic procedures has helped medicine reduce the amount of exploratory surgery needed. But detailed images have been blurred at times because of multiple echo reverberations. So the technology has been limited for early detection of smaller tumors or tissue changes.
The new SURF imaging helps resolve this problem and should help with detection of smaller tumors in breast cancer, prostate cancer, and thyroid cancer, as well as enhance information using contrast agents. It can also be used with cardiovascular diseases such as aneurysms or arteriosclerosis.
Professor Angelsen in Trondheim believes the technology should be ready for use within a year (Norwegian University of Science and Technology, 2008).
Prostate Cancer News: Altered Hormones From Antibacterial Soap
We all know that washing our hands with soap helps prevent diseases. But there is conflicting evidence on the appropriateness of some antibacterial products.
Many studies have shown the potential for synthetic chemicals from household products, such as antibacterial cleansers, to alter male and female hormones.
This process is called endocrine disruption. Chemicals with this effect can contribute to the development of cancer, reproductive problems, and developmental anomalies, as seen in laboratory studies.
A new study has shown that a chemical commonly used for antibacterial soaps not only alters male hormones, but in ways not previously reported.
The chemical is triclocarban, or TCC, or 3,4,4'-triclorocarbanilide. The U. S. imports about one million pounds of this chemical every year to add to bar soaps, detergents, body soap, antibacterial wipes, and other antibacterial cleansers.
Researchers have now shown that triclocarban changes the genetic expression that is normally regulated by testosterone in human cells. Also male rats exposed to this chemical through ingestion developed hypertrophy of the prostate gland (Lasley B, University of California Davis, 2007). This study is considered preliminary.
Hypertrophy of the prostate is a serious condition and has been associated with increased risk of prostate cancer.
Prostate Cancer News: New Hope For Prostate Cancer Research
Cancer research has a history of finding promising chemicals that end up having too many limitations for use.
One such chemical is tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) which increases the destruction (apoptosis) of prostate cancer cells.
But TRAIL has shown increasing drug resistance.
Now a new study has shown that the addition of EGCG from green tea sensitizes prostate cancer cells so that TRAIL becomes effective again.
When EGCG was present, TRAIL showed increased prostate cancer destroying activity through multiple chemical pathways. It increased the availability of cellular chemicals that destroy cancer and reduced the availability of chemicals that protect cancer. It improved the cancer cell death-inducing signals. And EGCG helped TRAIL synergistically to reduce the migration and invasion of prostate cancer cells (Siddiqui IA, Oncogene, 2007).
Green tea has shown facilitation of chemotherapy and radiation in other drug-resistant cancer studies also.
Prostate Cancer News: Prostate Cancer In Black Men
Prostate cancer in African-American men recurs more often after the completion of treatment programs than it does in white men.
Researchers compared medical records of 953 white men and 658 black men after radical prostatectomy. There were significant differences between the two groups.
Researchers found that black men were 28% more likely to have prostate cancer return as shown by a positive PSA (prostate-specific antigen) test (Freedman S, Cancer, 2007).
Despite the increased risk of prostate cancer recurrence, it was not significantly more aggressive among black men.
Increased screening for early detection gives the best opportunity for treatment success. Please see a licensed health care provider for prostate cancer screening procedures.
Many studies have shown prostate cancer risk reduction with long-term daily green tea intake: 90% prevention, and 72%-91% prevention. In addition, soy and cruciferous vegetables like broccoli and cauliflower may help protect against prostate cancer.
African-American men currently have the highest rates of prostate cancer in the whole world.
Prostate Cancer News: Prostate Cancer Awareness
Did you know that prostate cancer can start by age 20?
Did you know that prostate cancer is the second leading cause of cancer related deaths for men?
Did you know that prostate cancer can be present and growing for decades before a man can feel symptoms?
Did you know that prostate cancer claims 80% of men by the time they are 80 years old?
Did you know that a 12 year follow-up of men taking daily aspirin for at least 5 years found 20% prevention of prostate cancer?
Did you know that a 7 year trial of finasteride, a drug approved for benign prostatic hyperplasia, showed 25% lower risk of prostate cancer??
Did you know that almost 80 studies, including a controlled hospital study in China showed that drinking green tea showed between 74% and 91% lower risk of prostate cancer?
Did you know that almost 100% of prostate cancer can be cured if it is detected early enough?
Do you know if you are at risk?
Check with your licensed health care provider to find out now.
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